Publications by authors named "K G Franchini"

Background: Acute coronary syndrome (ACS) is one of the leading causes of mortality worldwide. Knowing the predisposing factors is essential for preventing it.

Objectives: To describe the etiological and epidemiological characteristics of the population with ACS admitted to an emergency room in the State of São Paulo.

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  • - Studies indicate that blood flow to the renal medulla is crucial for regulating blood pressure and pressure-natriuresis.
  • - Research in rats suggests that proper medullary blood flow is essential for balancing blood pressure and that reduced blood flow can lead to hypertension.
  • - Enhanced blood flow in the medulla can lower hypertension, and nitric oxide production in this area is vital for protecting against damage caused by various harmful agents.
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  • The study critiques the current classification of acute myocardial infarction (AMI) into STEMI and NSTEMI, stating it doesn't adequately capture the complexities of acute coronary syndromes.
  • It proposes a new framework called occlusion myocardial infarction (OMI) and non-occlusion myocardial infarction (NOMI) to improve diagnosis and management methods for AMI.
  • The research emphasizes the importance of quick ECG assessments and immediate treatments for OMI cases, aiming to enhance patient outcomes and encouraging further investigation in the cardiology field.
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  • - The study aimed to assess how effectively ST-segment elevation on a 12-lead ECG identifies acute coronary occlusions (ACO), questioning traditional STEMI vs. NSTEMI diagnostic classifications.
  • - After analyzing three studies with nearly 24,000 patients, it was found that ST-segment elevation has a low sensitivity (43.6%) for detecting ACO, suggesting many cases may not show this elevation, but it has high specificity (96.5%).
  • - An alternative diagnostic approach, the OMI-NOMI strategy, demonstrated improved sensitivity (78.1%) while keeping a similar high specificity, indicating a need for broader research to validate these findings in different contexts.
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Background: Heart Failure with Preserved Ejection Fraction (HFpEF) is a syndrome characterized by different degrees of exercise intolerance, which leads to poor quality of life and prognosis. Recently, the European score (HFA-PEFF) was proposed to standardize the diagnosis of HFpEF. Even though Global Longitudinal Strain (GLS) is a component of HFA-PEFF, the role of other strain parameters, such as Mechanical Dispersion (MD), has yet to be studied.

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