[Effect of ucrinol on lipid metabolism in liver tissue].

Alterations in content of phospholipids as well as dynamics of lipid free-radical oxidation were studied in the hepatocytes of the rats poisoned with various doses of the toxic agent ucrinol within 1.3 and 6 months. Low concentrations of the toxin (1.

[Oxidative processes and phospholipid metabolism in hepatocyte membranes during alloxan diabetes].

Total content of phospholipids and their individual components were distinctly increased in microsomal, mitochondrial fractions and in inner mitochondrial membrane of rat hepatocytes under conditions of alloxan diabetes. The concentrations of these substances were decreased in outer mitochondrial membrane. Activation of lipid free-radical oxidation was found in all the membrane structures studied.

[Interrelation of the processes of lipid peroxidation and hydroxylation in the liver microsomal fraction of white rats with alloxan diabetes].

Alloxan diabetes was accompanied by an increase in ascorbate-NADPH-dependent lipid peroxidation with a simultaneous decrease in content of cytochrome P-450 and in the rate aniline hydroxylation in rat liver microsomal fraction. Activation of lipid peroxidation, which led to impairment of the endoplasmic reticulum integrity as well as to destruction of cytochrome P-450, may be important in pathogenesis of alloxan diabetes.

[Phospholipid-phospholipid relations and changes of free radical lipid oxidation in biological membranes during alloxan diabetes].

Quantitative and qualitative composition of phospholipids as well as lipid peroxidation were studied in outer and inner mitochondrial membranes and microsomal fraction from rat liver tissue under conditions of alloxane diabetes. In the diabetes amount of phospholipids, mainly cardiolipins and phosphatidylethanolamines, was increased in the inner and decreased in the outer mitochondrial membranes. Phosphatidylcholines and phosphatidylserines were increased in microsomal fraction.

[Peroxidative and antioxidative activity of lipids in experimental pancreatitis].

Peroxidation of lipids and alteration in antioxidative activity were studied in normal state and in experimental pancreatitis within 1, 3, 7, 14 and 30 days after the operation. Experimental pancreatitis was accompanied by increase in content of lipid peroxides and by decrease in antioxidative activity of lipids extracted from liver tissue. Administration of thiosulfate decreased slightly the lipid peroxides content and increased the level of antioxidants in pancreatitis.