Publications by authors named "K Furuhata"
Living bodies comprise approximately 55-75% water to maintain homeostasis. However, little is known about the comprehensive differences in in vivo water molecule dynamics (water structure dynamics; WSD) between physiological and pathophysiological statuses. Here, we examined the WSD of ex vivo tumor tissues and organs from tumor-bearing mice with engrafted mouse malignant melanoma cells (B16-F10) in the right flanks to compare with those in healthy mice, using time domain reflectometry of dielectric spectroscopy at days 9, 11, and 14 after engrafting.
View Article and Find Full Text PDFThe stimulation of local immunity by vaccination is desirable for controlling virus replication in the respiratory tract. However, the local immune stimulatory effects of adjuvanted vaccines administered through the non-mucosal route are poorly understood. Here, we clarify the mechanisms by which non-mucosal inoculation of adjuvants stimulates the plasmacytoid dendritic cell (pDC)-dependent immunoglobulin (Ig)A response in the lungs.
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- VHH antibodies, derived from camelids, offer benefits like small size, easy production in bacteria, and adaptability for improvements.
- The study created a VHH phage display library from alpaca B cells immunized with Legionella pneumophila to develop a detection system.
- A sensitive latex agglutination assay for detecting Legionella was successfully established, aiming to improve detection of this serious pneumonia-causing pathogen.
Article Synopsis
- Aluminum salt adjuvants (Als) are commonly used in vaccines and can enhance immune response, but they may also cause chronic pain and other serious side effects in rare cases.
- A study on guinea pigs showed varying degrees of muscle damage from different Al-containing vaccines, with the human papillomavirus vaccine causing the most severe inflammation and damage.
- Despite this, the muscle injury observed was found to be repairable within a month, and the extent of damage seemed more related to the type of vaccine or aluminum salts used rather than the amount of aluminum.
Systematic Motion Integration with Multiple Depth Cameras Allowing Sensor Movement for Stable Skeleton Tracking.
Annu Int Conf IEEE Eng Med Biol Soc
July 2022
In recent years, markerless motion capture using a depth camera or RGB camera without any restriction on the subject has been attracting attention. Especially, depth cameras such as Kinect and RealSense allow instantaneous motion capture even at home outside lab environment, which is attractive for rehabilitation usage. However, single depth camera can capture steadily skeleton only when the subject stands facing to camera for the limited range, thus it is hard to apply to track skeletons while walking.
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