Publications by authors named "K Funatsu"
Reactions commonly used in synthetic organic chemistry are named after their discoverers or developers. They are called the name reactions and generally consist of several elementary reactions. Quantum chemical calculations can optimize transition state (TS) structures of the elementary reactions.
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- The octanol/water partition coefficient (logP) is crucial for understanding how well substances can pass through cell membranes, which affects their pharmacokinetics when taken orally.
- A study estimated logP values for about 200 diverse chemicals through experiments using their retention times in reverse-phase liquid chromatography and compared these with known values from authentic reference compounds.
- The findings revealed a strong correlation (r > 0.72) between experimental and in silico logP values for many compounds, but also highlighted the need for more diverse reference materials to improve logP estimation methods.
This study aimed to evaluate the effect of preoperative rehabilitation on postoperative hospital stay in elderly lung cancer patients following lung resection. This was a retrospective observational study using the Japanese Diagnosis Procedure Combination database. Data of patients diagnosed between April 2016 and March 2020 were collected.
View Article and Find Full Text PDFInfluenza is a respiratory infection caused by the influenza virus that is prevalent worldwide. One of the most contagious variants of influenza is influenza A virus (IAV), which usually spreads in closed spaces through aerosols. Preventive measures such as novel compounds are needed that can act on viral membranes and provide a safe environment against IAV infection.
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