Publications by authors named "K Funakawa"
Article Synopsis
- A 75-year-old woman was diagnosed with clinical stage III lung cancer and received chemoradiotherapy followed by durvalumab, an immune checkpoint inhibitor, which led to liver dysfunction classified as a grade 3 adverse event.
- Subsequent hospitalization revealed liver injury linked to immune-related adverse effects, with a liver biopsy showing features similar to autoimmune hepatitis, particularly the presence of specific lymphocyte infiltration.
- Pulse steroid therapy was initiated to address the liver dysfunction, highlighting the challenges of managing adverse effects from immune checkpoint inhibitors, particularly as their use is on the rise in cancer treatment.
Leucine-rich repeat kinase 2 (LRRK2), the major causative gene product of autosomal-dominant Parkinson's disease, is a protein kinase that phosphorylates a subset of Rab GTPases. Since pathogenic LRRK2 mutations increase its ability to phosphorylate Rab GTPases, elucidating the mechanisms of how Rab phosphorylation is regulated by LRRK2 is of great importance. We have previously reported that chloroquine-induced lysosomal stress facilitates LRRK2 phosphorylation of Rab10 to maintain lysosomal homeostasis.
View Article and Find Full Text PDFThe usefulness of endoscopy for diagnosing histological type remains unclear. This study aimed to examine the diagnostic accuracy of white light endoscopy (WLE), magnified endoscopy with narrow band imaging (NBI-ME), and NBI-ME with acetic acid enhancement (NBI-AA) for histological type of gastric cancer. Patients with depressed-type gastric cancers resected by endoscopic submucosal dissection were prospectively enrolled, and 221 cases were analyzed.
View Article and Find Full Text PDFBackground And Study Aims: Although endoscopic submucosal dissection (ESD) is an established therapy for colon neoplasms including laterally spreading tumors (LSTs), its application to advanced fibrotic lesions is very difficult owing to the thin walls of the large intestine. We examined the ability of preoperative endoscopic ultrasonography (EUS) to predict lesion fibrosis in patients undergoing colorectal ESD.
Patients And Methods: From 2009 to 2013, 58 LSTs were evaluated retrospectively with EUS and treated using colorectal ESD.