Publications by authors named "K Fukutsu"
Article Synopsis
- - This study explores the link between retinal vascular area (VAFP) and arterial stiffness, measured by brachial-ankle pulse wave velocity (baPWV), using a deep-learning algorithm on retinal photos from 372 individuals.
- - Results show that both total arteriolar area (AA) and total venular area (VA) are negatively correlated with baPWV, indicating that larger retinal vessel areas may be associated with lower arterial stiffness.
- - The findings suggest that retinal vessel measurements could be used as a potential biomarker for assessing systemic arterial stiffness, establishing a significant relationship between retinal images and cardiovascular health.
ROCK1 Mediates Retinal Glial Cell Migration Promoted by Acrolein.
Front Med (Lausanne)
September 2021
Acrolein is a highly reactive aldehyde that covalently binds to cellular macromolecules and subsequently modulates cellular function. Our previous study demonstrated that acrolein induces glial cell migration, a pathological hallmark of diabetic retinopathy; however, the detailed cellular mechanism remains unclear. The purpose of this study was to investigate the role of acrolein in retinal glial cell migration by focusing on rho-associated coiled-coil-containing protein kinases (ROCKs).
View Article and Find Full Text PDFThe Expression of Matrix Metalloproteinases in Eyes with Intraocular Lymphoma.
Ocul Immunol Inflamm
December 2022
Purpose: The purpose of this study is to investigate matrix metalloproteinases (MMPs) expression in human intraocular lymphoma (IOL).
Methods: Two enucleated eyes and seven cell-block samples obtained from patients with IOL who underwent vitrectomy were used. Immunopathological examinations were performed for detection of MMP-2, MMP-9, and TIMP-4 expressions.
Article Synopsis
- A novel deep learning algorithm was developed to evaluate retinal vessel changes due to hypertension by analyzing fundus photographs from over 5,500 health-check participants.
- The study involved automatic extraction and categorization of retinal arterioles and venules, measuring their areas, and correlating these with age and blood pressure.
- Results showed significant correlations between the areas of arterioles and venules, with both areas negatively correlating with age and blood pressure, suggesting the algorithm could serve as a new indicator of hypertension-related vascular changes.
In the event of an accident at a nuclear fuel handling facility, the wounds of affected workers may be contaminated with plutonium. The current approach for identifying plutonium contamination is by detecting α-particles in the blood stream. However, the applicability of this approach is impeded due to the α-particles being easily shielded by the bodily fluid components.
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