Immune Response to an Adjuvanted Recombinant Zoster Vaccine in Japanese Patients with Rheumatoid Arthritis Receiving Upadacitinib (End Zoster-J Study): Study Protocol for an Exploratory Parallel Triple-Arm Prospective Trial.

: Janus kinase (JAK) inhibitors have emerged as a new class of disease-modifying anti-rheumatic drugs in the treatment of rheumatoid arthritis (RA). However, herpes zoster is one of the common adverse events of JAK inhibitors, including upadacitinib, which is especially high in Japanese patients with RA compared to those from Western countries. Recombinant zoster vaccine (Shingrix) is an adjuvanted subunit vaccine containing varicella-zoster virus (VZV) glycoprotein E (gE) that is effective in adults over 50 years of age.

Reconstruction of the finger pulp with palmar digital artery perforator propeller flap using a digital artery perforator at the lateral base of the finger pulp.

Purpose: The digital artery perforator (DAP) flap is used to repair finger pulp defects as it can help preserve the digital artery. The standard DAP flap donor site is dorsal or lateral; however, the color of the flap typically poorly matches that of the finger pulp. The purpose of this study is to report two types of novel palmar DAP flaps.

Long-term in vivo performance of silicone membrane lungs coated with novel methacryloyloxyethyl phosphorylcholine polymers: A pilot study.

Background: This study was designed to evaluate the long-term durability, oxygenation, and pressure loss of newly developed, methacryloyloxyethyl phosphorylcholine (MPC)-polymer-coated, nonporous silicone hollow fiber-membrane lungs in vivo using a pulmonary artery-to-left-atrium paracorporeal configuration.

Methods: An extracorporeal circuit from the pulmonary artery (device inflow) to the left atrium (device outflow) was established using dedicated composite vascular grafts in three healthy female goats for the prototype lung testing.

Results: Duration of testing the prototype lungs was 52, 57, or 100 days.

Short-term recurrence of stroke following misdiagnosis of carotid web masked by thrombus.

Background: Carotid webs are a potential cause of occult cerebral infarction. Although they occur frequently, proper diagnosis and treatment are crucial; surgery has been shown to provide a good outcome. Although thrombus on the carotid web have been reported, digital subtraction angiography (DSA)-confirmed cases of pre-dispersed thrombus are rare.