Publications by authors named "K Frerichs"
Background And Objectives: The management of moyamoya disease during pregnancy and recommendations for the mode of delivery remain controversial. We investigated factors associated with neurologic events during pregnancy in women with moyamoya disease and its association with prepregnancy surgical revascularization.
Methods: We performed a literature search from January 1, 1970, through September 30, 2021, using Embase, Web of Science, Medline, and Cochrane to identify cases of moyamoya disease with pregnancy.
Cerebral vasospasm (CVS) is an important contributor to delayed cerebral ischemia following aneurysmal subarachnoid hemorrhage (aSAH), leading to high morbidity and long-term disability. While several microRNAs (miRNAs) have been implicated in vasospasm, the underlying mechanisms for CVS remain poorly understood. Our study aims to identify miRNAs that may contribute to the development of CVS.
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- Nearly all neurosurgeons in the U.S. will face a malpractice claim before they retire, so this study looks at trends in those lawsuits to help them understand their risks.
- Researchers checked databases for malpractice cases involving open brain surgery from 1987 to 2023, finding out details like how much money was awarded and what went wrong.
- Out of 1,550 cases studied, they found 252 related to surgery, with the average payout being about $2.75 million, and many claims were due to complications during or after surgery.
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- Bispecific antibodies teclistamab and talquetamab show effectiveness against multiple myeloma, but their mechanisms of resistance remain unclear.
- In laboratory studies on patients' bone marrow samples, the success of these treatments was linked to the balance of T cells and regulatory T cells in the samples.
- Resistance to BsAb treatment indicates issues like low ratios of T-cells to myeloma cells and immunosuppression from Tregs, which hinder T-cell activity and reduce treatment efficacy.
There has been an exponential increase in randomized controlled trials (RCTs) on cerebrovascular disease within neurosurgery. The goal of this study was to review, outline the scope, and summarize all phase 2b and phase 3 RCTs impacting cerebrovascular neurosurgery practice since 2018. We searched PubMed, MEDLINE, Embase, ClinicalTrials.
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