Publications by authors named "K Frankova"

Desmoplastic small round cell tumor is a very rare soft tissue sarcoma with a bleak prognosis and short patient survival. The most common occurrence is in 20-30-year-old men. Our study presents the case report of a 40-year-old patient who was diagnosed with this sarcoma.

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Desmoplastic small round cell tumor belongs to a group of soft tissue sarcomas. It is a rare disease, since its discovery in 1989, only hundreds of cases have been described in the literature. Due to the rare incidence of the tumor, this disease remains unknown in common medical practice.

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Article Synopsis
  • - Nanoparticle-loaded hydrogels combine the benefits of hydrogel (like sustained drug release) and nanoparticles (offering targeting and reduced toxicity); traditional designs use a polymer matrix for gel formation.
  • - The study introduces lipid nanocapsule (LNC)-based hydrogels that function without a polymer matrix by using a modified drug (CytC16) to link LNCs, resulting in a novel, gelled structure that retains useful viscoelastic properties.
  • - These innovative hydrogels offer controlled drug release and reduce toxicity risks post-administration since they leave no lingering gel residue, highlighting their potential as effective drug delivery systems.
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Citizens are increasingly called upon to comment on issues that directly concern them. However, such consultations may be tokenistic [1] as they occur with limited respondents, or may be at a time, or in a format which is inconvenient to the user. To encourage wider participation, the VoiceYourView project (vYv) has developed a system allowing people to make comments in a manner, time and place convenient to them.

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In this study we have compared the results of a method for the detection of cyclophosphamide in urine and the results of analysis of chromosomal aberrations in peripheral blood lymphocytes of four groups of subjects with various exposure statuses. These groups are 17 Dutch and 11 Czech exposed workers (mainly hospital nurses and pharmacy technicians) handling antineoplastic agents and 35 Dutch and 23 Czech controls (nurses, medical doctors, pharmacy and lab technicians) not handling these drugs. The groups were subdivided into smokers and non-smokers because of a confounding effect of smoking.

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