Müller cells and retinal angiogenesis: critical regulators in health and disease.

Müller cells are the most abundant glial cells in the mammalian retina. Their morphology and metabolism enable them to be in close contact and interact biochemically and physically with almost all retinal cell types, including neurons, pericytes, endothelial cells, and other glial cells, influencing their physiology by releasing bioactive molecules. Studies indicate that Müller glial cells are the primary source of angiogenic growth factor secretion in the neuroretina.

Update on Conventional Osteosarcoma.

Conventional osteosarcoma is a high-grade malignant tumor characterized by the production of osteoid matrix by malignant osteoblasts. It typically affects the long bones of children and adolescents. Treatment includes systemic chemotherapy and a local surgical approach with wide resection.

Modulation of cardiac autonomic activity across consciousness states and levels of sleep depth in individuals with sleep complaints and bipolar disorder or unipolar depressive disorders.

Objective: Autonomic nervous system dysfunction and reduced heart rate variability (HRV) often co-exist with mood disorders, a phenomenon likely influenced by sleep disturbances. This study investigated heart rate (HR) and HRV across wake, rapid eye movement (REM) sleep, and non-REM (NREM) sleep in individuals with sleep complaints and bipolar or unipolar depressive disorder.

Methods: Polysomnographic data was retrospectively collated for 120 adult patients with sleep complaints and depressive symptoms [60 diagnosed with bipolar disorder, 60 diagnosed with a unipolar depressive disorder], and 60 healthy controls.

Assessing the potential of nature-based solutions as sustainable land and water management strategies in the high tropical Andean páramo ecosystem.

Nature-based solutions (NbS) are gaining attention as viable strategies for restoring water-rich ecosystems such as the páramo. However, the lack of evidence on their effectiveness, coupled with a limited understanding of their political, economic, social, technological, environmental, and legal (PESTEL) context, hinders their widespread adoption. To address this gap, we propose a multi-method framework that (i) captures PESTEL factors influencing the implementation of passive ecological restoration in páramo ecosystems as a measure of NbS and (ii) assesses its associated environmental impacts.