The effect of sex hormones on glycosaminoglycan content of canine aorta and coronary arteries.

Hyaluronate (HA), heparan sulfate (HS), dermatan sulfate (DS) and isomeric chondroitin sulfates (CS) were measured in vascular walls of 9-10 months old normal and hypophysectomized female beagles treated with sex hormones. Following hypophysectomy the animals were maintained for 8 weeks without any hormonal replacement therapy and then they were exposed for 3 weeks to parenteral treatment with sex hormones. One group received twice weekly 25 mg testosterone, another group was given the same amount of progesterone, and a third group received on day 1 and day 14, estrogens in 2 injections, consisting of a mixture of 10 mg short-acting estradiol-17-phenylpropionate and 2.

Lack of somatotropin effect on glycosaminoglycan content of canine coronary arteries.

Eight beagles, 10 months of age, were surgically hypophysectomized and subsequently maintained without hormonal replacement therapy for 8 weeks. Four of the animals then received daily injections of bovine somatotropin (0.2 mg/kg subcutaneously for 3 weeks), while the remaining 4 were treated with saline.