Pitting base rate driven heuristics against conditional reasoning in multivariate contingency assessment.

Contingency assessment is a major module of adaptive cognition and a prominent topic of ecological rationality. Virtually all influential theories assume that contingency estimates between Y and X are inferred from subjective conditional probabilities of focal Y levels given different X levels, p ( Y focal | X different levels ) . Yet, conditional probabilities are cognitively demanding, as Yfocal must be assessed separately for all levels of Xdifferent level.

An autocrine synergistic desmin-SPARC network promotes cardiomyogenesis in cardiac stem cells.

The mammalian heart contains cardiac stem cells throughout life, but it has not been possible to harness or stimulate these cells to repair damaged myocardium in vivo. Assuming physiological relevance of these cells, which have evolved and have been maintained throughout mammalian evolution, we hypothesize that cardiac stem cells may contribute to cardiomyogenesis in an unorthodox manner. Since the intermediate filament protein desmin and the matricellular Secreted Protein Acidic and Rich in Cysteine (SPARC) promote cardiomyogenic differentiation during embryogenesis in a cell-autonomous and paracrine manner, respectively, we focus on their genes and employ mouse embryonic and cardiac stem cell lines as in vitro models to ask whether desmin and SPARC cooperatively influence cardiomyogenesis in cardiac stem and progenitor cells.

Rivals reloaded: Adapting to sample-based speed-accuracy trade-offs through competitive pressure.

Collecting an adequate amount of information for a decision is an important skill. However, previous experiments on speed-accuracy trade-offs in sample-based decisions revealed marked oversampling that was impervious to various interventions (Fiedler, McCaughey, et al., 2021).

Machine learning and molecular dynamics simulations aided insights into condensate ring formation in laser spot welding.

Condensate ring formation can be used as a benchmark in welding processes to assess the efficiency and quality of the weld. Condensate formation is critical as the resulting condensate settles into the powder thereby altering the quality of unconsolidated powder. This study investigates the intricate relationship between alloy composition, vapor pressure, and condensate ring thickness as seen in a two-dimensional micrograph.

Identification of a Therapeutic Window for Neurovascular Unit Repair after Experimental Spinal Cord Injury.

Traumatic spinal cord injury (SCI) is a devastating condition for which effective neuroregenerative and neuroreparative strategies are lacking. The post-traumatic disruption of the blood-spinal cord barrier (BSCB) as part of the neurovascular unit (NVU) is one major factor in the complex pathophysiology of SCI, which is associated with edema, inflammation, and cell death in the penumbra regions of the spinal cord adjacent to the lesion epicenter. Thus, the preservation of an intact NVU and vascular integrity to facilitate the regenerative capacity following SCI is a desirable therapeutic target.