Combined Martin-Gruber and complete Riché-Cannieu anastomoses disclosed during the electrodiagnostic evaluation of carpal tunnel syndrome.

Background: Electromyographers are frequently confronted by anomalous innervations and some may challenge the interpretation of nerve conduction studies (NCS). Reports of 2 or more anomalous innervations in the same patient are rare. I describe the NCS in a patient referred for an evaluation of carpal tunnel syndrome (CTS) who was found to harbor a combined Martin-Gruber anastomosis (MGA) and complete Riché-Cannieu anastomosis (RCA).

Protein-extending ACTN2 frameshift variants cause variable myopathy phenotypes by protein aggregation.

Objective: The objective of the study is to characterize the pathomechanisms underlying actininopathies. Distal myopathies are a group of rare, inherited muscular disorders characterized by progressive loss of muscle fibers that begin in the distal parts of arms and legs. Recently, variants in a new disease gene, ACTN2, have been shown to cause distal myopathy.

Multicenter expanded access program for access to investigational products for amyotrophic lateral sclerosis.

Introduction/aims: Expanded access (EA) is a Food and Drug Administration-regulated pathway to provide access to investigational products (IPs) to individuals with serious diseases who are ineligible for clinical trials. The aim of this report is to share the design and operations of a multicenter, multidrug EA program for amyotrophic lateral sclerosis (ALS) across nine US centers.

Methods: A central coordination center was established to design and conduct the program.