Copy Number Variation and Haplotype Analysis of 17q21.31 Reveals Increased Risk Associated with Progressive Supranuclear Palsy and Gene Expression Changes in Neuronal Cells.

Background: The 17q21.31 region with various structural forms characterized by the H1/H2 haplotypes and three large copy number variations (CNVs) represents the strongest risk locus in progressive supranuclear palsy (PSP).

Objective: To investigate the association between CNVs and structural forms on 17q.

RIFM fragrance ingredient safety assessment, cis-6-nonenal, CAS registry number 2277-19-2.

The existing information supports the use of this material as described in this safety assessment. cis-6-Nonenal was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, photoirritation/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analog decen-1-al (CAS # 65405-70-1) show that cis-6-nonenal is not expected to be genotoxic.