[Multi-injection treatment using an insulin pen].

100 diabetics (50 women and 50 men) with a mean age of 36.8 years (range 17-61) were converted from a conventional insulin regimen to multiple injections of rapidly acting insulin. Metabolic control was evaluated after a mean observation period of 17 months (range 4-32).

Concentration of endogenous oestradiol as related to oestradiol receptor sites in breast tumor cytosol.

Biopsies or mastectomy specimens from 69 malignant and 17 non-malignant human breast tumours have been examined with respect to cytoplasmic oestradiol receptors and endogenous oestradiol concentration. Of the malignant tumours, 45 (65%) had significant oestradiol receptor concentrations (136.7 fmol/mg protein +/- 38.

Oestrogen receptor values and histological grade in human breast cancer.

Histological grading of 126 oestrogen receptor positive and 81 oestrogen receptor negative breast carcinomas, using the WHO system, showed that some tumours in all grades had high receptor values, others low. There was no correlation between the receptor values and histological grade. It is suggested that factors other than the degree of dedifferentiation of the tumour may be responsible for the consistent tendency for receptor negative tumours to be placed in a high histological grade.

Radioimmunoassay of human chorionic gonadotropin beta-subunit as an early diagnostic test in ectopic pregnancy.

Serum HCG-beta has been assayed in 100 cases of ectopic pregnancy. Results above 10 IU/l were considered positive. Positive values were found in 97 cases, of which 23 were within the range of a normal pregnancy, one was above and 73 below the normal range.

Implications of oestrogen receptor status in primary breast carcinoma to the role of adjuvant chemotherapy in node-negative cases.

Recurrence occurred earlier in a small group of patients with node-negative breast carcinoma with oestrogen receptor (ER)-negative tumours, than in those in whom the tumour contained ER. The difference, indicative of an intrinsic advantage of an ER-positive tumour, was not seen following adjuvant chemotherapy. This finding could be explained on the basis of changes in the immunological balance between host and tumour brought about by treatment.