Publications by authors named "K F Ober"
Article Synopsis
- The research focuses on understanding proton bonds, which are important in various scientific fields, by examining them at very low temperatures (around 0.4 K) to minimize thermal fluctuations.
- A proton is placed within a molecular ring cavity created by a 12-crown-4 ether, and infrared laser spectroscopy reveals narrow vibrational bands that indicate a strong proton bond across the ether sites.
- Standard modeling techniques struggle to accurately describe the observed vibrational data due to the anharmonic nature of the proton bond, highlighting the need for advanced computational methods to analyze the dynamic behavior of the crown ether at different temperatures.
The stereoselective formation of 1,2- glycosidic linkages is challenging. The currently most widely used strategy for their installation uses 4,6--benzylidene-protected building blocks. The stereoselectivity of this reaction is thought to be driven by a covalent intermediate, which reacts via an S2 mechanism.
View Article and Find Full Text PDFHIV-infected cells persisting in the face of suppressive antiretroviral therapy are the barrier to curing infection. Cytotoxic immunoconjugates targeted to HIV antigens on the cell surface may clear these cells. We showed efficacy in mouse and macaque models using immunotoxins, but immunogenicity blunted the effect.
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- Understanding proton-bound complexes is important for grasping chemical reactivity and molecular interactions.
- This study focuses on the complex formed between dihydrogen phosphate and formate, using IR action spectroscopy in helium droplets.
- Findings reveal that contrary to expectations, protons are primarily located in the phosphate, and dynamics in partially deuterated complexes lead to changes in structure when IR light is applied.
There is growing recognition of the potential of migration to contribute to climate-change adaptation. Yet, there is limited evidence to what degree, under what conditions, for whom, and with which limitations this is effectively the case. We argue that this results from a lack of recognition and systematic incorporation of sociospatiality-the nested, networked, and intersectional nature of migration-as-adaptation.
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