Perspectives Toward COVID-19 Sanctions in the Orthodox Jewish Community in Brooklyn and Queens: A Qualitative Study of Medical Providers Experience.

The Ultra-Orthodox (Haredi) Jewish Community in New York City suffered significantly during the COVID-19 pandemic. The community came under public scrutiny after some members staunchly advocated for reopening of certain resources central to community culture. This study utilizes qualitative techniques to examine the perspectives of medical providers that serve the Haredi community toward pandemic-related government sanctions, as well as the resultant effects the restrictions had on community receipt of healthcare.

Nanoscale characterization of space weathering in lunar samples.

Nanoscale Fourier transform infrared (Nano-FTIR) imaging and spectroscopy correlated with photoluminescence measurements of lunar Apollo samples with different surface radiation exposure histories reveal distinct physical and chemical differences associated with space weathering effects. Analysis of two sample fragments: an ilmenite basalt (12016) and an impact melt breccia (15445) show evidence of intrinsic or delivered Nd and an amorphous silica glass component on exterior surfaces, whereas intrinsic Cr and/or trapped electron states are limited to interior surfaces. Spatially localized 1050 cm/935 cm band ratios in Nano-FTIR hyperspectral maps may further reflect impact-induced shock nanostructures, while shifts in silicate band positions indicate accumulated radiation damage at the nanoscale from prolonged space weathering due to micrometeorites, solar wind, energetic x-rays and cosmic ray bombardment.

Genetic/Familial High-Risk Assessment: Colorectal, Endometrial, and Gastric, Version 3.2024, NCCN Clinical Practice Guidelines In Oncology.

Multigene panel testing has allowed for the detection of a growing number of inherited pathogenic/likely pathogenic variants in people at high risk of cancer, including endometrial cancer (EC). Hereditary syndromes associated with EC include Lynch syndrome, PTEN hamartoma tumor syndrome, and Peutz-Jeghers syndrome. This manuscript provides the latest recommendations from the NCCN Guidelines for Genetic/Familial High-Risk Assessment: Colorectal, Endometrial, and Gastric on the screening and management of EC in patients at high risk for these syndromes, as well as the advantages and limitations of multigene panel testing.

Discovery of a Small Molecule with an Inhibitory Role for RAB11.

RAB11, a pivotal RabGTPase, regulates essential cellular processes such as endocytic recycling, exocytosis, and autophagy. The protein was implicated in various human diseases, including cancer, neurodegenerative disorders, viral infections, and podocytopathies. However, a small-molecular inhibitor is lacking.