Publications by authors named "K F Huybrechts"
Importance: In pregnancy, the benefits of lithium treatment for relapse prevention in psychiatric conditions must be weighed against potential teratogenic effects. Currently, there is a paucity of information on how and when lithium is used by pregnant women.
Objective: To examine lithium use in the perinatal period.
Study Question: What are the roles of maternal preconception diabetes and related periconceptional hyperglycemia on the risk of major congenital malformations (MCMs) in offspring?
Summary Answer: Maternal periconceptional glycated hemoglobin (HbA1c) levels over 5.6% were associated with an increased risk of congenital heart defects (CHD) in the offspring, and maternal preconception diabetes was associated with an increased risk of CHD, including when HbA1c levels were within euglycemic ranges.
What Is Known Already: Maternal preconception diabetes has been linked with MCMs in the offspring.
Article Synopsis
- The study focuses on understanding the risk of spontaneous abortion (SAB) and termination using Medicaid healthcare data, requiring accurate algorithms to estimate gestational age (GA).
- Researchers created a hierarchical algorithm to classify pregnancy outcomes and developed three approaches to estimate GA: using median GA, random distribution, and regression models.
- The best-performing approach utilized random forest models and achieved 58.0% accuracy for SAB and 66.3% for terminations within 2 weeks of the gold standard, highlighting the feasibility of studying these outcomes despite some misclassification issues.