Publications by authors named "K F Hostettler"
Background: Honeycomb cysts (HC) within the alveolar region are distinct histopathological features in the lungs of idiopathic pulmonary fibrosis (IPF) patients. HC are lined with a single-or stratified layer of basal cells (BC), or with a bronchiolar-like epithelium composed of basal-, ciliated- and secretory epithelial cells. By using cultured IPF patient-derived alveolar BC, we aimed to establish an in vitro- and in vivo model to mimic HC formation in IPF.
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- High bacterial load in lung microbiota is linked to the progression of idiopathic pulmonary fibrosis (IPF), and azithromycin (AZT), a macrolide antibiotic, may influence lung microbiota positively in IPF patients.
- A study involving 24 adults with IPF revealed that a 3-month AZT treatment significantly reduced community diversity in lung microbiota and changed the relationship between upper and lower airway microbiota.
- Results indicated that AZT led to lasting alterations in the microbiota diversity and composition, affecting how the upper and lower airways interacted over time.
Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease and is associated with high mortality due to a lack of effective treatment. Excessive deposition of the extracellular matrix by activated myofibroblasts in the alveolar space leads to scar formation that hinders gas exchange. Therefore, selectively removing activated myofibroblasts with the aim to repair and remodel fibrotic lungs is a promising approach.
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