Effect of a standard exercise protocol on shoulder pain in long-term wheelchair users.

Purpose: To analyze the effectiveness of a 6-month exercise protocol on shoulder pain experienced by wheelchair users during functional activities.

Subjects: Forty-two wheelchair users, 35 males and seven females: average age of 35 years and an average duration of wheelchair use of 14 years.

Methods: Subjects were randomly assigned to treatment (n=21) and control (n=21) groups.

Preparation, characterization, and antitumor properties of cis-PtCl2 complexes linked to anthraquinones through position number 2.

A new series of platinum-anthraquinone complexes of the type cis-PtLL'Cl2 [where L is the monodentate AQ-NH-(CH2)n-NH2 and L' = NH3 or LL' is the bidentate ligand AQ-NH-(CH2)n. NH-(CH2)2-NH2] in which the anthraquinone is linked to the diaminedichloroplatinum (II) moiety through position 2 was prepared and screened in vitro for antileukemic activity against P388 cells. All ligands were characterized by 1H and 13C NMR spectroscopy and all complexes by 195Pt NMR.

Conjugates of cis-4-hydroxy-L-proline and poly(PEG-Lys), a water soluble poly(ether urethane): synthesis and evaluation of antifibrotic effects in vitro and in vivo.

Synthetic approaches for the preparation of macromolecular conjugates of the antifibrotic agent cis-4-hydroxy-L-proline (cHyp) were explored, and the efficacy of the conjugates in inhibiting collagen accumulation was investigated in vitro and in vivo. In one approach, poly(PEG-Lys), an alternating copolymer of poly(ethylene glycol) (PEG) and lysine, was used as the carrier. To prepare pendent chain systems, cHyp was attached to poly(PEG-Lys) through an amide linkage [poly(PEG-Lys-cHyp amide)] or through an ester linkage [poly(PEG-Lys-cHyp ester)].

Antifibrotic effect of a proline analogue delivered in liposomes to cells in culture.

Proline analogues inhibit procollagen triple helix formation and are antifibrotic in vivo. Efficacy of the proline analoguecis-4-hydroxy-L-proline (cHyp) on vascular collagen accumulation is improved by in vivo delivery in liposomes. This effect may be due to local release of drug from liposomes taken up by vascular endothelium.

Preparation, characterization, and anticancer activity of a series of cis-PtCl2 complexes linked to anthraquinone intercalators.

A new series of complexes of the type cis-PtL2X2 [where L is a monodentate AQ-Y(CH2)nNH2 and L2 is a bidentate AQ-Y(CH2)nNH(CH2)2NH2; AQ = anthraquinone, X = Cl, I, Y = NH, O] in which anthraquinone intercalators are tethered to the cis-PtCl2 unit via an (aminoalkyl)amino, (oxyalkyl)amino, or polyethylene glycol (aminoethyl)amino linker chains was prepared and screened in vitro against P388 leukemia. In vivo toxicity studies were carried out on selected complexes. All complexes were characterized by means of elemental analysis, 195Pt NMR spectroscopy, and FTIR.