Publications by authors named "K F Firth"
Globus Pallidum DBS for Task-Specific Dystonia in a Professional Golfer.
Tremor Other Hyperkinet Mov (N Y)
December 2018
Article Synopsis
- Cardiomyocytes derived from human induced pluripotent stem cells (hiPSCs) are effective for modeling long QT syndrome (LQTS), particularly LQTS2, caused by mutations in the KCNH2 gene affecting potassium ion channels.
- β-blockers are the main treatment for LQTS but may not work for about 25% of patients, as they don't address the prolonged QT interval characteristic of the condition.
- The study found that drugs enhancing potassium currents significantly reduced action potential duration (APD) in LQTS-hiPSC-CMs, indicating potential new therapeutic options, like PPARδ agonists, for improving patient outcomes.
A highly tunable phosphine-imine ligand family is introduced. Following metallation with ruthenium, deprotonation of the ligand affords a phosphine-enamido species. Complexes with the ligand in both the imine and enamido forms are active toward acceptorless dehydrogenation reactions.
View Article and Find Full Text PDFSmall molecule absorption by PDMS in the context of drug response bioassays.
Biochem Biophys Res Commun
January 2017
The polymer polydimethylsiloxane (PDMS) is widely used to build microfluidic devices compatible with cell culture. Whilst convenient in manufacture, PDMS has the disadvantage that it can absorb small molecules such as drugs. In microfluidic devices like "Organs-on-Chip", designed to examine cell behavior and test the effects of drugs, this might impact drug bioavailability.
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