[Necessity and significance in basic and clinical research of liver xenotransplantation].

Liver transplantation is the only effective cure for end-stage liver disease. However,donor liver shortage has become a major problem,limiting the development of liver transplantation. Among the many ways to solve the problem of donor liver shortage,xenotransplantation has high feasibility and prospect of clinical application.

Development and evaluation of protective immunity of a ROP27 DNA vaccine against Eimeria tenella in chickens.

This study aimed to develop and evaluate the protective immunity of a ROP27 DNA vaccine against Eimeria tenella (E. tenella) in chickens. E.

Cost-effectiveness of angiographic quantitative flow ratio-guided coronary intervention: A multicenter, randomized, sham-controlled trial.

Background: The FAVOR (Comparison of Quantitative Flow Ratio Guided and Angiography Guided Percutaneous Intervention in Patients with Coronary Artery Disease) III China trial demonstrated that percutaneous coronary intervention (PCI) lesion selection using quantitative flow ratio (QFR) measurement, a novel angiography-based approach for estimating fractional flow reserve, improved two-year clinical outcomes compared with standard angiography guidance. This study aimed to assess the cost-effectiveness of QFR-guided PCI from the perspective of the current Chinese healthcare system.

Methods: This study is a pre-specified analysis of the FAVOR III China trial, which included 3825 patients randomized between December 25, 2018, and January 19, 2020, from 26 centers in China.

Low Density Lipoprotein Cholesterol but not Statins is the Direct Cause of Intracerebral Hemorrhage.

Objective: To investigate the direct and indirect relationships between statin use, low-density lipoprotein cholesterol (LDL-C) levels, and intracerebral hemorrhage (ICH), providing new insights into this complex scientific question.

Methods: In this cohort study, UK Biobank data from 2006-2010 were used to construct Structural Equation Models of statin use, LDL-C, and ICH, including 414,253 participants with LDL-C data. Published Genome-Wide Association Studies data were used for drug-target Mendelian Randomization analysis.

Functional Complete Revascularization as Determined by an Optimized Scoring System After Revascularization: A Post Hoc Analysis from Multi-Center PANDA III Trial.

Functional complete revascularization (CR) after percutaneous coronary intervention (PCI) as determined by classic residual functional SYNTAX score (c-rFSS) has been associated with improved prognosis. In this study, the c-rFSS algorithm is optimized for a novel modified rFSS (m-rFSS) and prognostic implications of this novel scoring is determined. The m-rFSS algorithm is updated for 2 clinical scenarios, i.