Publications by authors named "K F Cofer"

Article Synopsis
  • - Environmental heat stress is a major concern for warfighters, athletes, and workers, leading to exertional heat illness (EHI) that can cause severe health issues and long-term problems like cardiovascular dysfunction.
  • - A study invested genetic factors related to EHI by using whole-exome sequencing on 53 cases, finding that 30.2% of participants had clinically significant gene variants across 14 different genes, some of which are linked to muscle disorders and thermoregulation.
  • - Notably, the p.Arg905Trp variant was identified to hinder the thermal sensitivity of the TRPM4 channel, suggesting a new molecular mechanism of susceptibility to EHI, and highlighting the complexity of its genetic causes.
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Introduction: Enhanced recovery programs (ERPs) reduce racial disparities in surgical outcomes for general colorectal surgery populations. It is unclear, however, if disparities in IBD populations are impacted by ERPs.

Methods: Retrospective study comparing IBD patients undergoing major elective colorectal operations before (2006-2014) and after (2015-2021) ERP implementation using ACS-NSQIP data.

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Objective: To evaluate whether burnout was associated with emotional intelligence and job performance in surgical residents.

Design: General surgery residents at a single institution were surveyed using the Maslach Burnout Inventory (MBI) and trait EI questionnaire (TEIQ-SF). Burnout was defined as scoring in 2 of the 3 following domains; Emotional Exhaustion (high), Depersonalization (high), and Personal Accomplishment (low).

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We compared global levels of DNA methylation as well as methylation of a specific locus (MyoD1) in ovarian cystadenomas, ovarian tumours of low malignant potential (LMP) and ovarian carcinomas to investigate the association between changes in DNA methylation and ovarian tumour development. As we realized that cystadenomas showed different methylation patterns from both LMP tumours and carcinomas, we verified their monoclonal origin as a means of confirming their true neoplastic nature. High-pressure liquid chromatographic (HPLC) analyses showed that global methylation levels in LMP tumours and carcinomas were 21% and 25% lower than in cystadenomas respectively (P = 0.

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