Publications by authors named "K Erler"
Article Synopsis
- * Factors such as higher education and income were linked to better PROMs, while specific brain injuries affected performance ratings differently, highlighting the impact of socioeconomics and brain health on recovery perceptions.
- * The research identified a connection between parietal lobe damage and poorer self-reported outcomes, suggesting that injuries affecting self-awareness can distort patients' assessments of their own capabilities.
Article Synopsis
- The study aimed to understand personal, clinical, and environmental factors linked to four unique participation profiles in individuals with traumatic brain injury (TBI) one year or more post-injury.
- Participants included 408 individuals from the TBI Model Systems who completed phone interviews about their experiences and backgrounds.
- The analysis revealed key distinctions among the participation profiles based on factors like education, employment, community type, and cognitive function, highlighting trends in how these factors influence engagement in community activities.
The cellular response to oxidants or xenobiotics comprises two key pathways, resulting in modulation of NRF2 and FOXO transcription factors, respectively. Both mount a cytoprotective response, and their activation relies on crucial protein thiol moieties. Using fumaric acid esters (FAEs), known thiol-reactive compounds, we tested for activation of NRF2 and FOXO pathways in cultured human hepatoma cells by dimethyl/diethyl as well as monomethyl/monoethyl fumarate.
View Article and Find Full Text PDFTo characterize societal participation profiles after moderate-severe traumatic brain injury (TBI) along objective (Frequency) and subjective (Satisfaction, Importance, Enfranchisement) dimensions. We conducted secondary analyses of a TBI Model Systems sub-study ( = 408). Multiaxial assessment of participation included the Participation Assessment with Recombined Tools-Objective and -Subjective questionnaires (Participation Frequency and Importance/Satisfaction, respectively) and the Enfranchisement Scale.
View Article and Find Full Text PDFBackground And Objectives: The classic and singular pattern of distal greater than proximal upper extremity motor deficits after acute stroke does not account for the distinct structural and functional organization of circuits for proximal and distal motor control in the healthy CNS. We hypothesized that separate proximal and distal upper extremity clinical syndromes after acute stroke could be distinguished and that patterns of neuroanatomical injury leading to these 2 syndromes would reflect their distinct organization in the intact CNS.
Methods: Proximal and distal components of motor impairment (upper extremity Fugl-Meyer score) and strength (Shoulder Abduction Finger Extension score) were assessed in consecutively recruited patients within 7 days of acute stroke.