Publications by authors named "K Englund"
Introduction: Pre-transplant obesity and weight gain after heart transplantation are both associated with increased risk of poor clinical outcomes. We aimed to assess the association between overweight or obesity, exercise capacity, and health-related quality of life in heart transplant recipients.
Methods: This study is based on baseline data from the IronIC trial, in which we randomized 102 heart transplant recipients with iron deficiency to ferric derisomaltose or placebo.
Background: Following COVID-19 infection, as many as a third of patients have long-term symptoms, known as post-acute sequelae (PASC). The mechanisms contributing to PASC remain largely unknown and, due to the heterogeneity of symptoms, treating PASC provides unique challenges.
Objective: Our study sought to (1) identify clinical symptom profiles based on PROMIS Global Health (GH) items, (2) evaluate demographic and clinical differences across profiles, and (3) identify predictors of change in health-related quality of life (HRQL) over time.
Article Synopsis
- The study investigates the thrombosis risk and platelet function in patients with postacute sequelae of COVID-19 (PASC), also known as Long COVID, approximately 15 months after SARS-CoV-2 infection.
- Findings showed a mild increase in platelet aggregation through the thromboxane receptor but a decrease in activation through the glycoprotein VI receptor, alongside reduced thrombosis and Factor Xa activity in PASC patients compared to healthy controls.
- The results suggest a dysregulated platelet response in PASC patients, potentially due to a circulating molecule promoting thrombosis, as well as a protective mechanism that counteracts the increased thrombosis associated with SARS-CoV-2 infection.
Article Synopsis
- Post-acute sequelae of COVID-19 (PASC), also known as Long-COVID, can lead to changes in platelet function and thrombosis risk, which are not fully understood.
- A study compared PASC patients to healthy controls 15 months post-infection, assessing platelet activation and thrombosis potential through various tests.
- Findings indicated altered platelet responses in PASC patients, including increased activation through the thromboxane receptor and a protective mechanism against thrombosis, suggesting a complex interplay of pro- and anti-thrombotic factors following COVID-19.
Introduction: Aortic graft infection (AGI) is a rare complication following endovascular aneurysm repair and is associated with substantial morbidity and mortality. The traditional management of AGI is intravenous antibiotic therapy and surgical explantation. In this case series, percutaneous drainage was used as a bridge therapy in the treatment of AGI.
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