Complexed prostate specific antigen: better test in the diagnosis of prostate cancer for the clinically relevant 2.5-4 ng/ml total PSA range.

Background: Data on utilizing complexed prostate specific antigen (cPSA) offering increased diagnostic performance over other available clinical parameters in diagnosis of prostate cancer is still controversial. Our objective was to determine diagnostic performance of cPSA compared to total prostate specific antigen (tPSA) and corresponding ratios for possible routine application.

Methods: In a prospective study including overall 315 consecutive men, 177 patients with suspicious digital rectal examination, and/or tPSA value > 2.

Changes in electrical and physiological properties of human blood during storage.

In this study, the relationship between physiological parameters and electrical impedance changes of human blood and their further clinical implications are investigated. The study is performed on 255 erythrocyte suspension samples derived from 51 male donors. The samples are stored at 4°C and measurements are done on the 0, 10, 21, 35and 42days of storage.

Analytical and clinical evaluation of a new urinary tumor marker: bladder tumor fibronectin in diagnosis and follow-up of bladder cancer.

Bladder cancer is the fourth most common malignant neoplasm in men and the tenth most common in women. Cystoscopy presents the gold standard for detection and monitoring of bladder cancer. However, it is an invasive and expensive procedure.

Acute Effects of 17ß-Estradiol and ATP on Endothelial Cells; Effects of Genistein and PMA on Calcium Response.

Various studies have shown that 17ß-estradiol (E2), has acute effects on cardiovascular system in addition to its genomic effect. Acute administration of E2 had been shown to increase intracellular free calcium concentration (Ca+2)i in human umbilical vein endothelial cells (HUVEC). The present study investigates the signalling pathway responsible for Ca+2 response to E2.