A comparison of dual gradient-echo and spin-echo fMRI of the inferior temporal lobe.

Magnetic susceptibility differences at tissue interfaces lead to signal loss in conventional gradient-echo (GE) EPI. This poses a problem for fMRI in language and memory paradigms, which activate the most affected regions. Two methods proposed to overcome this are spin-echo EPI and dual GE EPI, where two EPI read-outs are serially collected at a short and longer echo time.

Regional neuronal network failure and cognition in late-onset sporadic Alzheimer disease.

Background And Purpose: The severe cognitive deficits in Alzheimer disease are associated with structural lesions in gray and white matter in addition to changes in synaptic function. The current investigation studied the breakdown of the structure and function in regional networks involving the Papez circuit and extended neocortical association areas.

Materials And Methods: Cortical volumetric and diffusion tensor imaging (3T MR imaging), positron-emission tomography with (18)F fluorodeoxyglucose on a high-resolution research tomograph, and comprehensive neuropsychological assessments were performed in patients with late-onset sporadic Alzheimer disease, those with mild cognitive impairment, and elderly healthy controls.

MRI diffusion tractography study in individuals with schizotypal features: a pilot study.

Diffusion tensor imaging (DTI) studies have identified changes in white matter tracts in schizophrenia patients and those at high risk of transition. Schizotypal samples represent a group on the schizophrenia continuum that share some aetiological risk factors but without the confounds of illness. The aim of the current study was to compare tract microstructural coherence as measured by fractional anisotropy (FA) between 12 psychometrically defined schizotypes and controls.

Both the middle temporal gyrus and the ventral anterior temporal area are crucial for multimodal semantic processing: distortion-corrected fMRI evidence for a double gradient of information convergence in the temporal lobes.

Most contemporary theories of semantic memory assume that concepts are formed from the distillation of information arising in distinct sensory and verbal modalities. The neural basis of this distillation or convergence of information was the focus of this study. Specifically, we explored two commonly posed hypotheses: (a) that the human middle temporal gyrus (MTG) provides a crucial semantic interface given the fact that it interposes auditory and visual processing streams and (b) that the anterior temporal region-especially its ventral surface (vATL)-provides a critical region for the multimodal integration of information.

Group-averaged anatomical connectivity mapping for improved human white matter pathway visualisation.

Anatomical connectivity mapping (ACM) is a measure of anatomical connectivity obtained by initiating streamline diffusion tractography from all parenchymal voxels and then counting the number of streamlines passing through each voxel of the brain. ACM highlights WM structures that present multiple connections to the rest of the brain but not necessarily strong microstructural orientation coherence. In this study, ACM was used to develop an atlas of the human brain.