Publications by authors named "K El-Salem"
Background: Gait deficits are common among people with multiple sclerosis (PwMS). Therefore, investigating factors that may influence walking in PwMS is important. Previous studies in older adults and other neurological populations demonstrated the relationship between sleep quality and gait performance.
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- Recent studies show astrocytes play a key role in neuroinflammatory diseases like multiple sclerosis (MS), interacting with both CNS components and immune cells.
- Due to challenges in obtaining human astrocytes, their specific role in MS is not fully understood, prompting the development of an in vitro model in this study.
- Findings indicate that when treated with CSF from MS patients, astrocytes exhibit reduced pro-inflammatory markers while increasing neuroprotective growth factors, suggesting they help mitigate inflammation in MS.
Background: Poststroke depression among patients is well-recognized, while caregiver depression is understudied. The interaction between patient and caregiver depression is also unclear.
Methods: This cross-sectional and follow-up study recruited 108 patient-caregiver dyads after the first-ever stroke.
Article Synopsis
- The study aimed to evaluate how topical lidocaine gel affects discomfort during nerve conduction studies (NCS) compared to a placebo gel (K-Y gel).
- A total of 130 patients participated, with one palm treated with lidocaine while the other received K-Y gel, and pain levels were measured through two pain scales.
- Results demonstrated that patients experienced significantly less pain with lidocaine gel, particularly in certain subgroups, although the overall clinical relevance of the findings may require further exploration and better drug delivery methods.
Fear of falling (FOF) is highly prevalent in people with Parkinson's disease (PwPD) and contributes to high fall risk. Studies reporting on the relationship between falls, FOF, and non-motor factors such as cognitive function and sleep quality in Parkinson's disease are limited. This study aimed to investigate (1) the relationship of cognitive function and sleep quality with FOF, and history of falls in PwPD; (2) differences in cognitive function and sleep quality between Parkinson's disease fallers and non-fallers; and (3) a cut-off score for cognitive function and sleep quality to discriminate Parkinson's disease fallers from non-fallers.
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