Genome-wide association analysis of composite sleep health scores in 413,904 individuals.

Recent genome-wide association studies (GWASs) of several individual sleep traits have identified hundreds of genetic loci, suggesting diverse mechanisms. Moreover, sleep traits are moderately correlated, so together may provide a more complete picture of sleep health, while illuminating distinct domains. Here we construct novel sleep health scores (SHSs) incorporating five core self-report measures: sleep duration, insomnia symptoms, chronotype, snoring, and daytime sleepiness, using additive (SHS-ADD) and five principal components-based (SHS-PCs) approaches.

Trends in Venous Thromboembolic Events and Anticoagulation Prescriptions for Orthopaedic Surgery of the Shoulder.

Background: There is a paucity of literature discussing anticoagulation prescribing patterns after upper extremity orthopedic surgery. The purpose of this study is to use a large national database to identify trends in adverse events and anticoagulation prescribing following orthopedic shoulder surgery.

Materials And Methods: The TriNetX Research Network was utilized to identify all patients undergoing orthopedic shoulder surgery between January 2004 and December 2022.

NIAID Workshop Report: Systematic Approaches for ESKAPE Bacteria Antigen Discovery.

On 14-15 November 2023, the National Institute of Allergy and Infectious Diseases (NIAID) organized a workshop entitled "Systematic Approaches for ESKAPE Bacteria Antigen Discovery". The goal of the workshop was to engage scientists from diverse relevant backgrounds to explore novel technologies that can be harnessed to identify and address current roadblocks impeding advances in antigen and vaccine discoveries for the ESKAPE pathogens (, , , , and species). The workshop consisted of four sessions that addressed ESKAPE infections, antigen discovery and vaccine efforts, and new technologies including systems immunology and vaccinology approaches.

We cannot repeat history again: a call to action to centre indigenous leadership as we prepare for the next pandemic.

Indigenous communities worldwide continue to disproportionately bear the burden during pandemics due to ongoing health inequities and systemic exclusion from pandemic decision-making processes. As the global community prepares for the next pandemic, it is critical to prioritise Indigenous leadership and governance within public health responses. This commentary highlights successful models of Indigenous-led pandemic responses during COVID-19 in Canada and Australia.

Yarning about vaccinations: Empowering individuals to have supportive conversations with Aboriginal peoples about vaccinations, using a community-engaged approach.

Objective: This study assessed the effectiveness of Aboriginal-led vaccine workshops to enhance knowledge, confidence and supportive conversations regarding scheduled and recommended vaccinations for Aboriginal and Torres Strait Islander people in Hunter New England, New South Wales, Australia.

Methods: We adapted and indigenised an existing vaccine conversation program. Aboriginal and Torres Strait Islander and non-Indigenous people were recruited to workshops delivered either online or face to face.