Publications by authors named "K Eden"
Oral docetaxel plus encequidar - a phase 1 clinical trial.
Cancer Chemother Pharmacol
September 2024
Purpose: To determine the bioavailability, safety, and tolerability of a single dose of oral docetaxel plus encequidar (oDox + E) and compare its pharmacokinetic exposure with current standard of care IV docetaxel.
Introduction: Docetaxel is a taxane widely used as an anti-neoplastic agent. Due to low oral bioavailability secondary to gut P-glycoprotein (P-gp) efflux, its current use is limited to intravenous administration.
Article Synopsis
- Dysregulated colonic epithelial cell (CEC) proliferation is significant in colorectal cancer, with NF-κB-inducing kinase (NIK) playing a key role in regulating CEC regeneration and differentiation through noncanonical NF-kB signaling.
- Studies using knockout mice showed that the absence of NIK resulted in severe colitis, increased tumor burdens, and an altered microbiome favoring colitis, while the effects varied with the type of cell (CEC vs. myeloid) involved in NIK knockout.
- The research highlights the complex relationship between noncanonical NF-κB signaling and colorectal cancer, suggesting that targeting NIK may offer a strategic approach to managing gastrointestinal inflammation and cancer development.
Background: Young adults with low sexual health literacy levels may find it difficult to make informed decisions about contraceptive methods. We developed and pilot-tested a web-based decision aid-Healthy Sex Choices-designed to support diverse young adults with their contraceptive decision-making.
Objective: This pilot study aimed to evaluate whether the Healthy Sex Choices decision aid is acceptable and feasible to patients and clinicians.
Objective: To investigate the effect of the South East Ontario Vision Rehabilitation Service (SOVRS), a centrally administered, regionally delivered vision rehabilitation service, on access to vision rehabilitation care.
Design: Pre-implementation (n = 1196) and post-implementation (n = 414) observational study.
Participants: Patients referred for low-vision assessment at the hospital-based Kingston Health Sciences Centre Vision Rehabilitation Clinic and community-based Southeastern Vision Loss Rehabilitation Ontario clinics from 2014 to 2019.
Pancreatic cancer is a malignant disease associated with poor survival and nearly 80% present with unresectable tumors. Treatments such as chemotherapy and radiation therapy have shown overall improved survival benefits, albeit limited. Histotripsy is a noninvasive, non-ionizing, and non-thermal focused ultrasound ablation modality that has shown efficacy in treating hepatic tumors and other malignancies.
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