Development of a Synthetic Platform for Ent-Pimaranes Reveals their Potential as Novel Non-Redox Active Ferroptosis Inhibitors.

We present a comprehensive account on the evolution of a synthetic platform for a subfamily of ent-pimaranes. For the most complex member, norflickinflimiod C, five distinct strategies relying on either cationic or radical polyene cyclizations to construct the requisite tricyclic carbon scaffold were explored. Insights from early and late stage oxidative and reductive dearomatization studies ultimately led to a mild, rhodium-catalyzed arene hydrogenation for the final synthetic route.

A General Entry to Meroterpenoids: Synthesis of Applanatumol E, H, and I, Lingzhilactone B, Meroapplanin B, and Lingzhiol.

meroterpenoids are fungal derived hybrid natural product class containing a 1,2,4-trisubstituted benzene ring and a polycyclic terpenoid part. The representatives applanatumol E, H and I, lingzhilactone B, and meroapplanin B share the same bicyclic lactone moiety connected to the arene. Employing photo-Fries rearrangements as the key step enabled a general entry to these natural products.

Ion-Pairing Stereodynamic Probes for Circular Dichroism Chiral Sensing of Amines.

Tris(2-pyridylmethyl)amine () and tris(2-phenolmethyl)amine () metal complexes have been extensively used for catalysis and molecular recognition applications. In particular, due to their ability to form stereodynamic complexes through the helical arrangement of the ligand around the metal in a propeller shape, chiroptical sensing has been extensively investigated. In particular, the capability of the analyte, usually a Lewis base, to bind the metal complex has been the predominant recognition motif.

Circular Melt-Spun Textile Fibers from Polyethylene-like Long-Chain Polyesters.

As textiles contribute considerably to overall anthropogenic pollution and resource consumption, increasing their circularity is essential. We report the melt-spinning of long-chain polyesters, materials recently shown to be fully chemically recyclable under mild conditions, as well as biodegradable. High-quality uniform fibers are enabled by the polymers' favorable combination of thermal stability, crystallization ability, melt strength, and homogeneity.

Novel ligands from direct benzylic functionalisation of tris(2-pyridylmethyl)amine.

Tris-(2-pyridylmethyl)amines (TPA or TPMA) are polipyrydine-based ligands extensively used in catalysis and supramolecular chemistry due their capability to form stable tetradentate complexes with a large variety of metals. The unsubstituted ligand, which is also commercially available, can be synthesised by consecutive alkylation of a picoline or by reductive amination of a pyridine aldehyde. In this article, we report a novel synthetic method which opens to the post-functionalisation of these ligands in the benzylic position.