Implementation Analysis of a Nurse-Led Observation Unit.

Objective: This implementation analysis of a nurse-led observation unit describes the development process and analyzes patients' characteristics, patient satisfaction, and provider perceptions.

Background: A nurse-led observation unit was developed to create more inpatient bed capacity and place patients in the clinical area best suited to their needs.

Methods: Descriptive statistics and content analysis were used for analysis.

Rac mediates TNF-induced cytokine production via modulation of NF-kappaB.

TNF is a key factor in a variety of inflammatory diseases. Here we report that TNF induced pro-inflammatory cytokine synthesis of IL-6 and IL-8 is mediated by the Rho GTPase Rac. TNF induces p42/p44, p54 and p38 MAPK kinase; these kinases have been implicated in control of cytokine synthesis.

Adenoviral targeting of signal transduction pathways in synovial cell cultures.

Methods for high efficiency gene transfer into primary cells of various lineages and disease states are desirable, as they remove the uncertainties associated with using transformed cell lines. Adenoviruses have evolved to deliver their genes into cells with high efficiency and in recent years have been exploited as a gene transduction system. Prior to the discovery of adenoviruses, efficient expression of transgenes was only possible by cloning stably transfected cells; this was limited to cell lines and was not an option for primary cells.

Effect of a ginger extract on pregnancy-induced nausea: a randomised controlled trial.

Objective: To investigate the effect of a ginger extract (EV.EXT35) on the symptoms of morning sickness.

Design: Double-blind randomised placebo-controlled trial.

Serenoa repens extract for benign prostate hyperplasia: a randomized controlled trial.

Objective: To compare the effect of a Serenoa repens extract with placebo for symptoms of benign prostatic hyperplasia (BPH).

Patients And Methods: In a double-blind placebo-controlled randomized trial between January 1999 and March 2000, 100 men with symptoms of BPH, aged < 80 years, with a maximum urinary flow rate of 5-15 mL/s for a voiding volume of 150 mL, were randomly and equally allocated to 320 mg S. repens extract or placebo (paraffin oil).