Publications by authors named "K E WEIGLE"
Background: Equine embryonic loss following the development of endometrial cups delays return to cyclicity due to the production of equine chorionic gonadotropin (eCG). Natural degradation of endometrial cups coincides with an influx of immune cells at 100-120 days of gestation, but therapeutic stimulation of reduced eCG production has been relatively unsuccessful. Recently, we observed an increase in pro-inflammatory cytokine production following the use of the immunostimulant mycobacterium cell wall fraction (MCWF).
View Article and Find Full Text PDFPosttransplant immunosuppressive drugs such as tacrolimus have narrow therapeutic ranges. Inter- and intraindividual variability in dosing requirements conventionally use physician-guided titrated drug administration, which results in frequent deviations from the target trough ranges, particularly during the critical postoperative phase. There is a clear need for personalized management of posttransplant regimens to prevent adverse events and allow the patient to be discharged sooner.
View Article and Find Full Text PDFIn the last 30 years, operative, technical and medical advances have made liver transplantation (LT) a life-saving therapy that is used worldwide today. Global industrialization has been a contributor to morbid obesity and this has brought about the metabolic syndrome along with many downstream complications of such. Non-alcoholic steatohepatitis (NASH) has become a recognized hepatic manifestation of the metabolic syndrome and NASH cirrhosis is predicted to be the primary indication for LT in the United States by 2025.
View Article and Find Full Text PDFArticle Synopsis
- American cutaneous leishmaniasis is a significant health concern in Colombia, with around 6,000 new cases reported annually, primarily managed through diagnosis and treatment.
- A group-randomized trial was conducted in 20 matched villages in Tumaco to assess the effectiveness of a multifaceted intervention involving bednets, repellents, sand fly habitat modifications, and health education over one year.
- Results showed a 58% reduction in leishmaniasis cases in the intervention group compared to the control group, particularly benefiting children under 10 and those in higher prevalence areas, although the small number of cases limits the conclusiveness of the findings.
Objectives: To examine whether access to care factors account for racial/ethnic disparities in influenza vaccination among elderly adults in the United States.
Design: Indicators of access to care (predisposing, enabling, environmental/system, and health need) derived from Andersen's behavioral model were identified in the National Health Interview Survey questionnaire. The relationship of these indicators to influenza vaccination and race/ethnicity was assessed with multiple logistic regression models.