Publications by authors named "K E Szabo-Taylor"
Spinal muscular atrophy (SMA) is an autosomal recessive disease leading to progressive muscle weakness and atrophy, in severe cases also affecting the bulbar and respiratory muscles.The clinical spectrum of the disease is extremely variable, in the most severe cases resulting in perinatal death, while at the least severe end of the spectrum causing some motor deficits in old age without the loss of ambulation. Spinal muscular atrophy care has changed dramatically in recent years due to the availability of new therapeutic options.
View Article and Find Full Text PDFObjectives: An imbalanced redox homeostasis resulting in oxidative stress is present in preeclampsia. Peroxiredoxin-1 (PRDX1) and thioredoxin-1 (TRX1) regulatory enzymes are also contributing to the redox homeostasis, but were not investigated so far in preeclampsia. Thus, we have aimed to characterize PRDX1, TRX1 and oxidative stress biomarkers in blood samples of pregnant women with preeclampsia.
View Article and Find Full Text PDFFormation of a protein corona on the surface of extracellular vesicles in blood plasma.
J Extracell Vesicles
September 2021
Article Synopsis
- The study investigated the formation of a protein corona around extracellular vesicles (EVs) in blood plasma from healthy individuals and rheumatoid arthritis patients, using various isolation and analysis techniques.
- It was found that plasma protein-coated EVs exhibited higher density and carried several newly associated proteins, confirming interactions through advanced imaging and assay methods.
- Notably, the research identified nine proteins common among EVs, viruses, and nanoparticles, and revealed that while these EVs influenced dendritic cell activity, EV-free protein aggregates did not have any effect, offering new insights into EV research.
Extracellular vesicles such as exosomes, microvesicles, apoptotic bodies, and large oncosomes have been shown to participate in a wide variety of biological processes and are currently under intense investigation in many different fields of biomedicine. One of the key features of extracellular vesicles is that they have relatively large surface compared to their volume. Some extracellular vesicle surface molecules are shared with those of the plasma membrane of the releasing cell, while other molecules are characteristic for extracellular vesicular surfaces.
View Article and Find Full Text PDFAims: The prognosis of patients with pancreatic cancer has remained virtually unchanged with a high mortality rate compared to other types of cancers. An earlier detection would provide a time window of opportunity for treatment and prevention of deaths. In the present study we investigated extracellular vesicle (EV)-associated potential biomarkers for pancreatic cancer by directly assessing EV size-based subpopulations in pancreatic juice samples of patients with chronic pancreatitis or pancreatic cancer.
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