Publications by authors named "K E Salhany"
Obesity is associated with increased incidence and metastasis of triple-negative breast cancer, an aggressive breast cancer subtype. The extracellular matrix (ECM) is a major component of the tumor microenvironment that drives metastasis. To characterize the temporal effects of age and high-fat diet (HFD)-driven weight gain on the ECM, we injected allograft tumor cells at 4-week intervals into mammary fat pads of mice fed a control or HFD, assessing tumor growth and metastasis and evaluating the ECM composition of the mammary fat pads, lungs, and livers.
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- Metastasis is the leading cause of death in breast cancer, necessitating an understanding of tumor cell migration and its correlation between in vitro and in vivo behavior.
- In a study using immunocompromised mice, six human triple-negative breast cancer (TNBC) cell lines were evaluated for their tumor growth, metastasis, and characteristics such as morphology, proliferation, and motility.
- The findings categorized cell lines by their metastatic potential and showed that morphological metrics were the best predictors of tumor growth and metastasis, while in vitro motility assays did not significantly correlate with in vivo outcomes.
Younger age and obesity increase the incidence and metastasis of triple-negative breast cancer (TNBC), an aggressive subtype of breast cancer. The extracellular matrix (ECM) promotes tumor invasion and metastasis. We characterized the effect of age and obesity on the ECM of mammary fat pads, lungs, and liver using a diet-induced obesity (DIO) model.
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- Metastasis is a major cause of death in breast cancer, involving processes like local invasion and colonization of distant organs, which are poorly understood across different human breast cancer cell lines.
- This study classified six triple-negative breast cancer cell lines in a mouse model based on their tumor growth and metastasis characteristics, revealing varying levels of tumorigenicity and metastatic potential.
- The researchers found that cell morphology metrics were the best predictors of metastasis, while no single motility assay consistently correlated with metastatic potential.
Soft tissue tumors are uncommon manifestations of Epstein-Barr virus (EBV) infection in patients who have had transplants. The authors report 2 metachronous EBV-containing smooth muscle tumors in a child who had a heart transplant, and review the literature on posttransplant soft tissue tumors.
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