Publications by authors named "K E Roth"
Background: Biosimilar natalizumab (biosim-NTZ) is the first biosimilar monoclonal antibody of reference natalizumab (ref-NTZ) for treatment of relapsing forms of multiple sclerosis (MS). Within the totality of evidence for demonstration of biosimilarity, immunogenicity assessments were performed in healthy subjects and patients with relapsing-remitting MS (RRMS) to confirm a matching immunogenicity profile between biosim-NTZ and ref-NTZ.
Methods: Immunogenicity of biosim-NTZ versus ref-NTZ was evaluated in two pivotal clinical studies.
Pannexin (PANX) channels are present in skin and facilitate the movement of signalling molecules during cellular communication. PANX1 and PANX3 function in skin homeostasis and keratinocyte differentiation but were previously reduced in a small cohort of human cutaneous squamous cell carcinoma (cSCC) tumours compared to normal epidermis. In our study we used SCC-13 cells, limited publicly available RNA-seq data and a larger cohort of cSCC patient-matched samples to analyse PANX1 and PANX3 expression and determine the association between their dysregulation and the malignant properties of cSCC.
View Article and Find Full Text PDFA variety of osteotomies on the calcaneus have been described in the past to adapt the shape of the calcaneus to specific needs. Newer osteotomy and fixation methods allow the procedure to be as minimally invasive as possible. Recent data suggest that the minimally invasive surgery (MIS) techniques allow for fewer complications, particularly with regard to wound healing.
View Article and Find Full Text PDFproduces more guaiacol in media and has duplicate copies of compared to closely related .
Appl Environ Microbiol
November 2024
Article Synopsis
- Certain species in the genus are responsible for spoilage in beverages by producing guaiacol, a compound that creates off-aromas, yet there is limited understanding of the genes involved in this process.
- Researchers found that guaiacol-producing species have genes associated with oxidative stress, particularly a gene involved in the synthesis of guaiacol.
- It is important for the food industry to differentiate between species with high spoilage potential and those that do not produce guaiacol, as not doing so can lead to ineffective waste reduction strategies.
A biosimilar medicine is a successor to a reference ('originator'/'original-brand') biologic medicine brought to market once the patent and exclusive marketing rights for the reference have expired. Biosimilar natalizumab (PB006 [biosim-NTZ]; developed by Polpharma Biologics S.A.
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