Publications by authors named "K E OBERG"
Complex organic molecules are widespread in different areas of the interstellar medium, including cold areas, such as molecular clouds, where chemical reactions occur in ice. Among the observed molecules are oxygen-bearing organic molecules, which are of high interest given their significant role in astrobiology. Despite the observed rich chemistry, the underlying molecular mechanisms responsible for molecular formation in such cold dilute areas are still not fully understood.
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- FLVCR1 is a protein involved in transporting essential compounds like heme and choline, with mutations linked to serious developmental disorders and neurodegenerative conditions in humans.
- Researchers identified 30 patients with biallelic FLVCR1 variants who displayed severe developmental issues, including brain malformations and other complications, paralleling symptoms seen in mouse models and conditions like Diamond-Blackfan anemia (DBA).
- The findings emphasize that FLVCR1 variants could cause a wide range of health problems, underscoring the need for diverse genetic testing and consideration of animal model data in understanding human genetic disorders.
Article Synopsis
- - The study highlights the importance of dorsoventral patterning in limb anatomy, which has not been as thoroughly researched as other developmental axes and involves key extensor and flexor muscles.
- - It discusses how the transcription factor Lmx1b is crucial for determining dorsal limb characteristics and its role in conditions like Nail-Patella syndrome, bringing attention to genetic and molecular implications.
- - The review also explores the connection between dorsoventral polarity and digit tip regeneration, aiming to encourage further investigation into this vital yet underrated aspect of limb function and evolution.
We report eight cases of complex radial polydactyly and/or ulnar dimelia each with a fistulous lesion of heterotopic respiratory mucosa in radial-anterior skin ranging from shoulder to wrist. Although speculative, the coincidence of these rare conditions suggests a mechanistic relationship.
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