Publications by authors named "K E Nava-Castro"
Article Synopsis
- Helminth infections in school-age children lead to cognitive deficits, and deworming treatment improves memory recall; similar effects are observed in mice with distinct differences between sexes.
- Male and female mice showed different parasite loads and changes in neurotransmitter levels, with males experiencing increased norepinephrine and serotonin in the hippocampus, while females had decreased levels.
- The study indicates that the brain's response to infection varies across different structures and can explain the behavioral changes seen in infected individuals, highlighting the complex interactions between the immune, endocrine, and nervous systems.
Introduction: In colorectal cancer, men exhibit a higher incidence than women, and there is a disturbance in the levels of sex steroids in serum in patients with this disease. Consistently, in animals, males have greater tumor growth than females in diverse models. Nevertheless, the role of sex steroids is not well established.
View Article and Find Full Text PDFIntroduction: Sexual dimorphism significantly influences cancer incidence and prognosis. Notably, females exhibit a lower risk and favorable prognosis for non-reproductive cancers compared to males, a pattern observable beyond the scope of risk behaviors such as alcohol consumption and smoking. Colorectal cancer, ranking third in global prevalence and second in mortality, disproportionately affects men.
View Article and Find Full Text PDFConvergence between helminths and breast cancer: intratumoral injection of the excretory/secretory antigens of the human parasite (EST) increase lung macro and micro metastasis.
Front Immunol
April 2024
Introduction: Worldwide, breast cancer is the most important cancer in incidence and prevalence in women. Different risk factors interact to increase the probability of developing it. Biological agents such as helminth parasites, particularly their excretory/secretory antigens, may play a significant role in tumor development.
View Article and Find Full Text PDFArticle Synopsis
- The study focuses on Toxocariasis, a helminth parasite linked to poverty and health issues like blindness and tumor growth, with limited research on sexual differences in infection response.
- Researchers analyzed liver and lung lesions, immune cell types, and cytokine and antibody production in infected male and female rats to investigate susceptibility differences.
- Results showed females had more larvae in the liver, while males had them in the lungs, with varied immune responses and lower antibody production observed in females compared to males.