Safety of baricitinib in vaccinated patients with severe and critical COVID-19 sub study of the randomised Bari-SolidAct trial.

Background: The Bari-SolidAct randomized controlled trial compared baricitinib with placebo in patients with severe COVID-19. A post hoc analysis revealed a higher incidence of serious adverse events (SAEs) among SARS-CoV-2-vaccinated participants who had received baricitinib. This sub-study aimed to investigate whether vaccination influences the safety profile of baricitinib in patients with severe COVID-19.

Broad Range Tuning of InAs Quantum Dot Emission for Nanophotonic Devices in the Telecommunication Bands.

InAs semiconductor quantum dots (QDs) emitting in the near-infrared are promising platforms for on-demand single-photon sources and spin-photon interfaces. However, the realization of quantum-photonic nanodevices emitting in the telecom windows with similar performance remains an open challenge. In particular, nanophotonic devices incorporating quantum light emitting diodes in the telecom C-band based on GaAs substrates are still lacking due to the relaxation of the lattice constant along the InGaAs graded layer which makes the implementation of electrically contacted devices challenging.

The Regensburg Dental Trauma Registry: Methodical Framework for the Systematic Collection of Dentoalveolar Trauma Data.

Traumatic dental injuries (TDIs) are common, particularly in children and adolescents, and require timely, well-documented treatment for optimal long-term functional and esthetic outcomes. Despite their prevalence, comprehensive data on TDI remain limited. The Regensburg Dental Trauma Registry (RDTR) was established to enable structured data collection, documentation and analysis of dentoalveolar trauma cases to improve both research and clinical practice.

Complete and Efficient Covariants for Three-Dimensional Point Configurations with Application to Learning Molecular Quantum Properties.

When physical properties of molecules are being modeled with machine learning, it is desirable to incorporate (3)-covariance. While such models based on low body order features are not complete, we formulate and prove general completeness properties for higher order methods and show that 6 - 5 of these features are enough for up to atoms. We also find that the Clebsch-Gordan operations commonly used in these methods can be replaced by matrix multiplications without sacrificing completeness, lowering the scaling from () to () in the degree of the features.

Degradation and stable maintenance of adeno-associated virus inverted terminal repeats in E. coli.

Current plasmid propagation in E. coli compromises large inverted repeats, such as inverted terminal repeats (ITRs) of adeno-associated virus (AAV). Direct long-read sequencing analyses upon varying strains and culture conditions revealed ITR instability caused by a slipped misalignment mechanism, although other mechanism probably contribute.