Evaluation of LPRDA Pentapeptide for the Prevention and Treatment of Peritoneal Infection.

Targeting virulence determinants is a promising approach to controlling infections in the face of the global spread of antibiotic resistance. -induced peritonitis often occurs in dialysis, implant and trauma patients. To develop novel prevention and treatment options for peritoneal infection, we investigated the oligopeptide sortase A inhibitor LPRDA as a non-conventional antibacterial that does not affect staphylococcal survival.

Ensemble Docking as a Tool for the Rational Design of Peptidomimetic Sortase A Inhibitors.

Sortase A (SrtA) of has long been shown to be a relevant molecular target for antibacterial development. Moreover, the designed SrtA inhibitors act via the antivirulence mechanism, potentially causing less evolutional pressure and reduced antimicrobial resistance. However, no marketed drugs or even drug candidates have been reported until recently, despite numerous efforts in the field.

Mid-IR lasing in HgCdTe multiple quantum well edge-emitting ridges.

Thin HgCdTe/CdHgTe quantum wells (QWs) grown on alternative GaAs (013) substrates have been recently proposed as a material for coherent emitters in the mid-IR region. In this work, we develop a technological process for the fabrication of ridge microresonators in waveguide heterostructures with multiple HgCdTe QWs via photolithography and ion etching. We process two samples with different ridge heights and analyze their emission spectra measured under optical excitation.

Pyrrolidine/Azepane Ring Expansion via Intramolecular Ullmann-Type Annulation/Rearrangement Cascade: Synthesis of Highly Functionalized 1-Benzazepines.

5-Arylpyrrolidine-2-carboxylates with an -halogen substituent at 5-aryl and an electron-withdrawing group at the C position of the pyrrolidine ring were transformed into 1-benzo[]azepine-2-carboxylates under Cu(I) promotion and microwave activation. Reaction promoter copper(I) thiophene-2-carboxylate has been generated in the reaction's environment from CuO and thiophene-2-carboxylic acid. Functionalized 1-benzo[]azepine-2-carboxylates were obtained in racemic and optically active forms in 67-89% yields.

Oligopeptide Sortase Inhibitor Modulates Cell Adhesion and Biofilm Formation.

Prevention of bacterial adhesion is one of the most important antivirulence strategies for meeting the global challenge posed by antimicrobial resistance. We aimed to investigate the influence of a peptidic sortase A inhibitor on bacterial adhesion to eukaryotic cells and biofilm formation as a potential method for reducing virulence. The pentapeptide LPRDA was synthesized and characterized as a pure individual organic compound.