[Features of organic nonelectrolyte binding to the erythrocyte membrane].

The capacity of erythrocyte membranes for organic nonelectrolytes from different chemical groups of chemical compounds was studied by the spin probe method and scanning electron microscopy. Hydrophobic spin-labeled derivatives of gamma-carbolin and stearic acid and the screened phenol antioxidant fenozan-1 were used as nonelectrolytes. Based on the analysis of electron spin resonance spectra of the hydrophobic spin-labeled nonelectrolytes and electron micrographs of erythrocytes, differences in the capacity of distribution regions in the intramembrane space of the derivative of gamma-carbolin and fenozan-1, on the one hand, and the spin-labeled derivative of fatty acid, on the other hand, were found.

[Changes in the surface architectonics of erythrocytes under the influence of the synthetic antioxidant fenozan-1].

Scanning electron microscopy revealed changes in erythrocyte morphology induced by the synthetic antioxidant phenozan-1. Phenozan-1 at 10(-7)-10(-5) M acts as an echinocytogen. This effect of the antioxidant is, probably, due to its distribution in the external monolayer of the erythrocyte membrane and associated structural changes.

[A comparative study of the action of 1-methyl-1-nitrosourea and 1,3-dimethyl-1-nitrosourea on tumor cell DNA in vitro and in vivo by the alkaline elution method].

DNA damage of the tumor cells was studied by the method of alkali elution from filters after introduction of 1-methyl-1-nitrosourea (MNU) and 1,3-dimethyl-1-nitrosourea (DMNU) to mice with Ehrlich ascites carcinoma or after treatment of the cultivated cells with these drugs. DNA was essay fluorometrically using DAPI. The degree of DNA damage was characterized by the constant of the alkali elution rate (Kae), which was estimated according to the anamorphism of the kinetic curves of elution.

[Structural and biochemical parameters of blood components of mice after gamma irradiation with small doses of different intensity].

The complex study on the low gamma-irradiation on the structural feature of lymphocyte DNA and lipid peroxidation (LPO) regulatory system parameters in mice blood was carried out depending on irradiation intensity. It was found that DNA alkaline elution rate constants, viscosity of the different regions of erythrocyte membranes and LPO products content in mice blood plasma varied nonlinearly depending on dose or dose rate. The proportion of the damage types and the range of the DNA structural changes substantially differ depending on the gamma-irradiation dose and its intensity.