Publications by authors named "K E Jarrett"
Background: The aim of this study was to ascertain risks of neonatal mortality, severe neurological morbidity and severe non-neurological morbidity related to the 5-min Apgar score in early term (37-38 weeks), full term (39-40 weeks), late term (41-41 weeks), and post term (≥42 weeks) infants.
Methods: This was a retrospective cohort study of 941,221 term singleton births between 2000 and 2018 in Queensland, Australia. Apgar scores at 5-min were categorized into five groups: Apgar 0 or 1, 2 or 3, 4-6, 7 or 8 and 9 or 10.
Cellular metabolism is tightly regulated by growth factor signaling, which promotes metabolic rewiring to support growth and proliferation. While growth factor-induced transcriptional and post-translational modes of metabolic regulation have been well defined, whether post-transcriptional mechanisms impacting mRNA stability regulate this process is less clear. Here, we present the ZFP36/L1/L2 family of RNA-binding proteins and mRNA decay factors as key drivers of metabolic regulation downstream of acute growth factor signaling.
View Article and Find Full Text PDFBackground: Removal of circulating plasma low-density lipoprotein cholesterol (LDL-C) by the liver relies on efficient endocytosis and intracellular vesicle trafficking. Increasing the availability of hepatic LDL receptors (LDLRs) remains a major clinical target for reducing LDL-C levels. Here, we describe a novel role for RNF130 (ring finger containing protein 130) in regulating plasma membrane availability of LDLR.
View Article and Find Full Text PDFHere, we present the complete chloroplast genome sequence of Toxicodendron diversilobum, western poison oak, from Pacific Grove, California. The genome is 159,543 bp in length, contains 133 genes, and has a high level of gene synteny to other species of .
View Article and Find Full Text PDFArticle Synopsis
- Changes in accessible plasma membrane cholesterol are linked to the Aster family's role in regulating cholesterol synthesis and metabolism in cell models, but their impact on living organisms was previously unclear.
- The study identifies two key situations in the liver—fasting and reverse cholesterol transport—where accessible PM cholesterol is generated and the Aster pathway is activated, highlighting the importance of these mechanisms.
- Aster-dependent cholesterol transport during fasting enhances cholesterol movement in the body, and loss of Asters leads to increased plasma cholesterol and accumulation in peripheral tissues, affecting overall lipid balance.