Publications by authors named "K E Jacobs"
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological disease originating from the malignant transformation of T-cell progenitors, caused by the accumulation of genetic aberrations. One-fifth of T-ALL patients are characterized by ectopic expression of the homeobox transcription factor TLX3. However, the role of TLX3 in T-ALL remains elusive, partly due to the lack of suitable study models.
View Article and Find Full Text PDFHereditary Hemorrhagic Telangiectasia (HHT) is an autosomal dominant vascular disorder with manifestations including severe nose bleeding and microhemorrhage in brains. Despite being the second most common inherited bleeding disorder, the pathophysiological mechanism underlying HHT-associated hemorrhage is poorly understood. HHT pathogenesis is thought to follow a Knudsonian two-hit model, requiring a second somatic mutation for lesion formation.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to analyze the prevalence of in-person visits and virtual communication methods (like phone and video calls) in ICUs across Australia and New Zealand, especially during the COVID-19 pandemic.
- Findings revealed that 77% of ICUs had visiting restrictions, with a significantly reduced median visiting time of 9 hours per day, resulting in only 65% of patients receiving in-person visits.
- The majority of in-person visits were for family interaction, while telephone calls were primarily for clinical updates, with visit patterns showing higher activity during daytime hours rather than the evening.