International survey on diagnostic reference levels based on clinical indications in plain radiography.

Purpose: To collect and analyze radiation dose-related data as part of international cooperation; to define diagnostic reference levels (DRL) for 24 X-ray projections in plain radiography (DX) considering anatomical region, clinical task, and procedural technique; and to harmonize the exposure practice across country borders.

Methods: A multicenter study was performed in Austria, Germany, Italy, and Switzerland in 2022-23 to provide dose-related data. Healthcare facilities were asked to provide processed data from their dose management systems.

Structural basis of thiamine transport and drug recognition by SLC19A3.

Thiamine (vitamin B) functions as an essential coenzyme in cells. Humans and other mammals cannot synthesise this vitamin de novo and thus have to take it up from their diet. Eventually, every cell needs to import thiamine across its plasma membrane, which is mainly mediated by the two specific thiamine transporters SLC19A2 and SLC19A3.

Introduction to Creating Feminist Futures: Research Methodologies for New Times.

What role do and might feminist methodologies, with their prioritisation of ethical and political questions and interventions, have in creating futures? What kinds of futures are needed? What kinds of feminist imaginations should be cultivated, and how? What world-making practices might feminism (further) develop and/or invent? In the context of war, climate breakdown, pandemics, the resurgence of far-right politics, political upheaval and poverty, this special issue examines the role of feminist methods in creating futures that are desirable and necessary. This introduction to the special issue argues that feminism is especially well-equipped to examine and build new futures and that imagining and making different worlds can be helpfully understood as methods. We sketch out four key themes that we see as significant within the wide, varied and growing literatures on feminist futures and that are particularly important for the contributions gathered together here: .

Everything is Patchwork! A Conversation about Methodological Experimentation with Patchwork Ethnography.

This article collectively discusses creative feminist approaches to ethnographic methods developed in response to challenging social, personal, environmental, and temporal conditions and pressures. Patchwork Ethnography, developed by Gökçe Günel, Saiba Varma and Chika Watanabe, recognises mundane pressures, and works with insights and experiences that emerge not only from doing research, but from what happens around the edges. By rendering the many 'seams' of research visible and valuable, their approach aims to develop creative, kind, and more generous - yet no less robust - research realities.

MFSD1 with its accessory subunit GLMP functions as a general dipeptide uniporter in lysosomes.

The lysosomal degradation of macromolecules produces diverse small metabolites exported by specific transporters for reuse in biosynthetic pathways. Here we deorphanized the major facilitator superfamily domain containing 1 (MFSD1) protein, which forms a tight complex with the glycosylated lysosomal membrane protein (GLMP) in the lysosomal membrane. Untargeted metabolomics analysis of MFSD1-deficient mouse lysosomes revealed an increase in cationic dipeptides.