Publications by authors named "K E Hurst"
Photocatalytic water splitting is a promising route to low-cost, green H. However, this approach is currently limited in its solar-to-hydrogen conversion efficiency. One major source of efficiency loss is attributed to the high rates of undesired side and back reactions, which are exacerbated by the proximity of neighboring oxidation and reduction sites.
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- The study focuses on improving resuscitation methods to minimize inflammation and organ damage after severe trauma-related blood loss.
- Researchers connected animal study data with real patient data from a trauma study using a mathematical model to analyze inflammation and coagulation responses.
- The model effectively predicted outcomes and showed that resuscitation with both plasma and red blood cells was more effective than using crystalloid solutions alone, while early plasma use improved survival and reduced injury severity.
Article Synopsis
- Phytophotodermatitis is a skin reaction caused by contact with plant chemicals (furocoumarins) and sunlight exposure, observed in a case study of a 34-year-old patient post-beach trip in Mexico.
- The patient's irregular hyperpigmented patch developed after handling lime during a margarita, linking the skin issue to both sun and citrus exposure.
- This case emphasizes the need for detailed patient history and examination to avoid misdiagnosis and inappropriate treatments for skin conditions that may appear similar.
Background: Participants who received ketamine at the NIMH were among the first to receive ketamine for depression in controlled clinical trials, providing a unique opportunity to assess long-term outcomes. This analysis evaluated the relationship between participating in a ketamine clinical trial and subsequent ketamine/esketamine use after leaving the research setting.
Methods: Participants seen within the NIMH Experimental Therapeutics and Pathophysiology Branch from 2002 to 2022 (n = 1000) were contacted for follow-up assessment.
The solid tumor microenvironment (TME) imprints a compromised metabolic state in tumor-infiltrating T cells (TILs), hallmarked by the inability to maintain effective energy synthesis for antitumor function and survival. T cells in the TME must catabolize lipids via mitochondrial fatty acid oxidation (FAO) to supply energy in nutrient stress, and it is established that T cells enriched in FAO are adept at cancer control. However, endogenous TILs and unmodified cellular therapy products fail to sustain bioenergetics in tumors.
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