Brain-wide neuronal circuit connectome of human glioblastoma.

Glioblastoma (GBM) infiltrates the brain and can be synaptically innervated by neurons, which drives tumor progression. Synaptic inputs onto GBM cells identified so far are largely short-range and glutamatergic. The extent of GBM integration into the brain-wide neuronal circuitry remains unclear.

Gehyra Geckos Prioritize Warm Over Humid Environments.

Maintaining stable hydric and thermal states are dual challenges for reptiles that inhabit terrestrial environments with variable conditions across time and space. Under some conditions, reptiles face a conundrum where both physiological parameters cannot be simultaneously maintained at preferred levels by behavioral or physiological means. Prioritization of behavioral regulation of hydric or thermal state, and at which point this prioritization changes, was tested for nine species of congeneric tropical geckos by assessing their use of microhabitats with distinct thermal and hydric conditions in a controlled environment.

Exposure to the antiretroviral drug dolutegravir impairs structure and neurogenesis in a forebrain organoid model of human embryonic cortical development.

Introduction: For many therapeutic drugs, including antiretroviral drugs used to treat people living with HIV-1 (PLWH), we have little data on the potential effects on the developing human brain due to limited access to tissue and historical constraints on the inclusion of pregnant populations in clinical trials. Human induced pluripotent stem cells (iPSCs) offer a new avenue to gain insight on how drugs may impact human cell types representative of the developing central nervous system. To prevent vertical transmission of HIV and promote the health of pregnant PLWH, antiretroviral therapy must be initiated and/or maintained throughout pregnancy.

Environmental impact assessment of SONARA's oil sludge landfill in BATOKE, south-west Cameroon.

The focus of this study was to assess the environmental impact of the BATOKE oil sludge dump. A field visit was conducted to evaluate the condition of the site, followed by the sampling of oil sludge, BATOKE river water, soil, and locally grown manioc and macabo tubers. Subsequent physico-chemical characterization revealed parameters such as pH, electrical conductivity, total hydrocarbons, COD, BOD5, TSS, major cations and anions, as well as heavy metals including iron, copper, zinc, nickel, chromium, lead, cadmium, mercury, arsenic, calcium, potassium, titanium, zirconium, and rubidium.