Expression of p53 Protein Associates with Anti-PD-L1 Treatment Response on Human-Derived Xenograft Model of GATA3/CR5/6-Negative Recurrent Nonmuscular Invasive Bladder Urothelial Carcinoma.

Background: The possible involvement of p53 signaling, FGFR3 expression, and mutation rates in the prediction of the NMIBC anti-PD-L1 treatment response needs to be clarified. The main aim of our study was to explore predictive value of p53 expression, FGFR3 expression, and its gene mutation status for the therapeutic success of anti-PD-L1 treatment in the patient-derived murine model of recurrent high-PD-L1(+) GATA3(-)/CR5/6(-) high-grade and low-grade NMIBC.

Methods: twenty lines of patient-derived xenografts (PDXs) of relapsed high-PD-L1(+) double-negative NMIBC were developed, of which 10 lines represented high-grade tumors and the other ones-low-grade bladder cancer.

[Indications and efficiency of various surgical interventions use as treatment of patients with odontogentic antritis caused by moved out filling material into maxillary sinus].

Indications to various surgical interventions methods of treatment of patients with odontogentic antritis caused by moved out filling material into maxillary sinus including endoscopic one were considered. Efficiency and indications to surgical intervention in 52 patients with the use of traditional operative access and in 20 patients with the use of endoscopic technique were analyzed.

[Change in temperature in young and old rats exposed to emotional-noise and immobilization stress].

Experiments with rats have shown that thermoregulation under normal conditions and in response to stressful factors (immobilization, emotionally significant sound) is different in animals of different age. The effect of these stressful factors leads to more significant temperature changes in the group of young animals, as compared with the adult ones.

[Effects of the bee and various snake venoms on the rat thermoregulation].

The most sensitive organ to any kind of venoms is the skin, whereas muscles response of milder, and the intestine response reveals no difference between effects of different venoms. The isobarin desympathetising effect combined with V.lebetina venom shows that the venom affects thermoregulation interacting with the sympathetic nervous system, and exerts a sympathomimetic effect.