Publications by authors named "K Dunlop"
Breakthroughs and challenges for generating brain network-based biomarkers of treatment response in depression.
Neuropsychopharmacology
November 2024
Treatment outcomes widely vary for individuals diagnosed with major depressive disorder, implicating a need for deeper understanding of the biological mechanisms conferring a greater likelihood of response to a particular treatment. Our improved understanding of intrinsic brain networks underlying depression psychopathology via magnetic resonance imaging and other neuroimaging modalities has helped reveal novel and potentially clinically meaningful biological markers of response. And while we have made considerable progress in identifying such biomarkers over the last decade, particularly with larger, multisite trials, there are significant methodological and practical obstacles that need to be overcome to translate these markers into the clinic.
View Article and Find Full Text PDFAtypical Brain Aging and Its Association With Working Memory Performance in Major Depressive Disorder.
Biol Psychiatry Cogn Neurosci Neuroimaging
August 2024
Article Synopsis
- - The study investigates how major depressive disorder (MDD) affects brain structure and cognitive function, particularly looking at how these changes relate to normal brain development and aging in adolescents and adults.
- - Researchers analyzed brain data from 304 participants with MDD and 236 without, finding that individuals with MDD had lower brain centile scores, indicating atypical brain aging, and those scores were linked to working memory only in the control group.
- - The findings suggest that MDD is associated with unusual brain development and aging, but severity of depression and childhood maltreatment did not significantly influence brain measurements or treatment responses.
Objective: To investigate the use of a virtual reality learning environment (VRLE) to enhance medical student knowledge of postpartum hemorrhage (PPH) emergency management and insertion of a postpartum balloon.
Methods: A randomized control trial involving medical students from University College Dublin, Ireland. Participants were randomly allocated to the intervention group (VRLE tutorial) or control group (PowerPoint tutorial on the same topic).
Background: Risk-tailored screening has emerged as a promising approach to optimise the balance of benefits and harms of existing population cancer screening programs. It tailors screening (e.g.
View Article and Find Full Text PDFBackground: Cancer screening that is tailored to individual risk has the potential to improve health outcomes and reduce screening-related harms, if implemented well. However, successful implementation depends on acceptability, particularly as this approach will require GPs to change their practice.
Aim: To explore Australian GPs' views about the acceptability of risk-tailored screening across cancer types and to identify barriers to and facilitators of implementation.