[Liberation of drugs from impregnated wound dressings].

The present paper investigates drugs and polymers intended for the impregnation of textile carriers intended for use as wound covers. Their suitability was evaluated on the basis of the evaluation of the antimicrobial efficacy of a combination of trimetoprim and sulfadimidine with the local anaesthetics carbizocaine and lidocaine, and the immunomodulating substance fungal glucan. A greater inhibitory effect on the growth of microorganisms was shown by a combination of antimicrobial substances with carbizocaine.

[Topical preparations for burns and their evaluation].

The study focused on some problems connected with the formulation of the topical preparation of the hydrocream type, intended for the treatment of dermal burns. Seven cream bases containing Emulgator E 2155, Polysorbate 80 and silicone oils were evaluated. The employed drugs included carbizocaine, lidocaine, chlorohexidine, and the immunomodulating substance glucan.

[Transdermal administration of drugs. XI. Formulation of polymeric matrices with metoprolol in transdermal therapeutic systems].

The paper is concerned with formulation studies of the transdermal therapeutic system of the matrix type with beta-adrenolytic drug metoprolol. The base of the hydrophobic matrix is the biocompatible polymer-silicone rubber, and the hydrophilic matrix was prepared from the polyacrylate polymer of the Eudragit type. The properties of the silicone matrix were modified by the additive Methocel F 4M, macrogol 600, copolymer p (HEMA) with methacrylic acid and polyacrylamide.

[A new topical preparation for the treatment of burns. I. Technical aspects of preparation].

In the present paper some problems connected with the formulation of a topical preparation of the hydro-ointment type intended for the treatment of deep dermal burns were examined. Sixteen ointment bases containing hydroxypropyl-methylcellulose, hydroxyethylcellulose, Carbopol 934 and Pluronic F-127 as gel-forming substances were evaluated. The local anaesthetic agents carbizocaine and lidocaine served as active ingredients.