Publications by authors named "K Drews"
Background: The goal of the PROPEL-IT study is to conduct an effectiveness-implementation (hybrid type 1) study to 1) test the effectiveness of a digital technology focused 24-month, patient-centered precision public health approach to weight-loss, facilitated by an electronic medical record (EMR) in Black patients with obesity and type 2 diabetes mellitus or prediabetes, and 2) better understand the external validity and context for implementation.
Methods: Patients in the Intensive Lifestyle Intervention (ILI) participate in a high-intensity behavioral intervention to facilitate weight loss through reducing dietary intake and increasing physical activity. The ILI is delivered by health coaches in the digital medicine program of a large health care organization facilitated by the patient portal of their EMR.
Article Synopsis
- Endometrial cancer (EC) is closely linked to obesity, particularly affecting young women, and identifying it early can improve treatment options, especially for those with severe obesity undergoing metabolic/bariatric surgery.
- A screening program using a modified questionnaire, called Modified SAMANTA, was implemented to identify women with abnormal or postmenopausal uterine bleeding (APUB) before their surgery to check for possible underlying endometrial issues.
- Over a study period from March 2021 to May 2023, nearly half of the 1371 women screened were found to have APUB, with higher prevalence linked to factors like increased BMI and certain racial demographics, highlighting the need for careful monitoring in these patients.*
From chromosomal aberrations to mutations in individual genes - the significance of genetic studies of chorions after miscarriage in the search for causes of miscarriages.
J Matern Fetal Neonatal Med
December 2024
Objective: To determine the frequency of chromosomal aberrations in chorions after a miscarriage. The second was to examine selected euploid chorions using a next-generation sequencing (NGS) panel designed to assess 43 genes associated with pregnancy loss.
Materials And Methods: The 1244 chorions were tested by targeted quantitative fluorescent PCR (QF-PCR, 827 chorions) and microarray-based comparative genomic hybridization (aCGH, 417 chorions).
Diabetes exposure during pregnancy affects health outcomes in offspring; however, little is known about in utero exposure to preexisting parental youth-onset type 2 diabetes. Offspring born to participants during the Treatment Options for Type 2 Diabetes in Adolescent and Youth (TODAY) study were administered a questionnaire at the end of the study. Of 457 participants, 37% of women and 18% of men reported 228 offspring, 80% from female participants.
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